Anti-CCRL2 Monoclonal Antibody

Dr. Brian Zabel and Prof. Eugene Butcher have developed rat monoclonal antibodies (clones BZ2E3 and BZ5B8, rIgG_2aκ isotype) to the mouse chemokine (CC motif) receptor-like 2 (CCRL2) protein. CCRL2 (formerly known as L-CCR) is expressed on mast cells, activated macrophages, and endothelial cells. It binds the leukocyte chemoattractant chemerin without triggering classical GPCR signaling, providing a specific mechanism for local enrichment of chemerin at inflammatory sites. CCRL2 presents active chemerin to leukocytes expressing the chemoattractant receptor CMKLR1/Chemr23. These anti-CCRL2 antibodies can be used in wide variety of assays to study leukocytes and immune response. Chemerin can block anti-CCRL2 antibody binding.