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Magnetic Sifter for Biomedical Detection


Stanford Reference:

05-306


Abstract


Stanford engineers have developed a patented device and sample preparation technique for high throughput purification, concentration, and sample preparation of a wide variety of biomolecules. This technology employs magnetic nanobead probes to tag molecules or cells of interest from raw samples. Then those tags are used to sift the molecules for purification with high capture efficiency. Recent developments in the sifter design allow for ultra-high capture and release efficiencies, high-throughput, simple interfacing with standard flow equipment, and the ability to perform cell separation in addition to biomolecule separations (such as DNA, RNA and proteins).

Ongoing Research
The inventors have ongoing studies directed at developing protocols for biomolecule and cell separation.


Applications


  • Sample preparation/purification for:
    • biological research
    • diagnostics
    • biowarfare detection
    • genomics and proteomics
    • collection and isolation of rare cells
  • Types of molecules that can be purified include:
    • DNA
    • RNA
    • proteins
    • pathogens
    • cells

Advantages


  • High throughput - greater than 1 ml/hr
  • Ultra-high capture and release efficiencies - greater than 95%
  • Multi-functional probes - the same probes can potentially be used for both capture and detection
  • Low cost, easy to use, simple design

Publications



Innovators & Portfolio



Patent Status



Date Released

 10/22/2010
 

Licensing Contact


Mona Wan
mona.wan@stanford.edu
650-498-0902 (Business)

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Related Keywords


biobeads   Pathogen Detection   magnetic beads   single cell detection   nanoelectronic detection   nucleic acid purification   protein separation   nanobiotechnology   microfluidic device   diagnostic: biochip   DNA RNA purification   DNA purification   DNA isolation   separation   diagnostic: detection   cell separation   capture and release   protein purification   protein detection   Sample preparation   purification   cell capture   cell sorting   magnetic tags   molecular separations   
 

   

  

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