Engineered EGF polypeptides for improved epidermal and epithelial wound healing

Applications

• Treatment of chronic wounds
• Cosmetic Application

Advantages

• EGF mutants have about 30 times more receptor-binding affinity than natural EGF

Publications

• US patent 8,247,531: Mutant epidermal growth factor polypeptides, nucleic acids, and uses therefor
• Cochran JR, Kim YS, Lippow SM, Rao B, Wittrup KD. Improved mutants from directed evolution are biased to orthologous substitutions. Protein Engineering, Design & Selection. 2006 Jun;19(6):245-53.

Related Technologies

• S11-262: Epidermal growth factor (EGF) mutants for wound healing and tissue engineering (details)

Related Links

• Cochran Lab
• Wittrup Lab

Patents

• Published Application: WO2007109673
• Published Application: 20080249008
• Issued: 8,247,531 (USA)