Anti-Pknox monoclonal antibody

Researchers in the laboratory of Dr. Michael Cleary at Stanford University have developed anti-Pknox monoclonal antibodies to study transcriptional regulation, embryonic development, and tissue homeostasis. The Meis/Pknox (also known as Prep) subfamily of TALE (three-amino acid loop extension)-class homeodomian proteins heterodimerze with Pbx proteins to form trimeric complexes with Hox proteins on appropriate DNA sites that regulate developmental gene expression. The anti-Pknox antibodies could be used in research related to leukemia, embryonic development, and tissue homeostasis.