Monoclonal antibody to CD6, Clone 34-3

Researchers at Stanford have created a monoclonal antibody to CD6. CD6 is a surface molecule expressed on T cells and some B cells. It may also play a role in diseases such as multiple sclerosis and rheumatoid arthritis. The precise function of CD6 in regulating T cell responses and in disease pathogenesis is still unclear. CD6 may also be used to identify regulatory T cells (Tregs) based on their low/negative CD6 expression. To further study the role of CD6, the inventors have developed this rat anti-mouse CD6 monoclonal antibody, IgG2b isotype. It can be used as a research tool to study CD6.

Stage of research
The antibody has been used to characterize CD6 expression in the mouse and investigate the role of CD6 in T cell development and function.