Anti-Meis Monoclonal Antibody

Researchers in the laboratory of Dr. Michael Cleary at Stanford University have developed anti-Meis monoclonal antibodies to study transcriptional regulation, embryonic development, and tissue homeostasis. Meis proteins are members of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins that are targets for oncogenic mutations in human and murine leukemias. The homeobox protein, Hoxb1, employs both Meis-related proteins and Pbx as essential cofactors to mediate its transcriptional effects on an endogenous Hox response element. The Meis protein is expressed in mouse hindbrain during embryonic development. In the medulla, Meis proteins appear to mediate the movement of Pbx3a into the nuclei of neurons. The anti-Meis antibodies could be used in research related to leukemia, embryonic development, and tissue homeostasis.