Docket #: S01-245H
Anti-Set1p monoclonal antibody
Researchers in the laboratory of Dr. Michael Cleary at Stanford University have developed anti-Set1p monoclonal antibodies to study chromatin regulation and histone methylation. Histone methylation has emerged as a modification for recruitment of proteins that determine transcriptional accessibility of genes. Set1p is a yeast protein that is a component of a seven-member complex that is required for a specific histone methylation. The anti-Set1p antibodies could be used to study chromatin remodeling as well as epigenetic regulation of developmental and sex-specific gene expression.
Applications
- Research of histone methylation related to:
- epigenetic regulation
- chromatin remodeling
- sex-specific gene expression
Publications
- Nagy PL, Griesenbeck J, Kornberg RD, Cleary ML., "A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3." Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):90-4. Epub 2001 Dec 18.