Docket #: S18-278
Hypoxia-mediated resistance of Homologous recombination-deficient cancer cells to PARP inhibitors
Stanford researcher's invivo studies find that combining PARP inhibitors with a hypoxia activated prodrug delays tumor growth.
Applications
- Combining PARP inhibitors with Hypoxia-targeting drugs in HR deficient cancer cells
Advantages
- Combining PARP inhibitors with Tirapazamine (hypoxia-activated drug) shows significantly higher tumor killing effects when compared to each monotherapy.
Patents
- Published Application: WO2020118251
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