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Docket #: S18-278

Hypoxia-mediated resistance of Homologous recombination-deficient cancer cells to PARP inhibitors

Stanford researcher's invivo studies find that combining PARP inhibitors with a hypoxia activated prodrug delays tumor growth.

Applications

  • Combining PARP inhibitors with Hypoxia-targeting drugs in HR deficient cancer cells

Advantages

  • Combining PARP inhibitors with Tirapazamine (hypoxia-activated drug) shows significantly higher tumor killing effects when compared to each monotherapy.

Patents

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