Docket #: S06-068
Inductive Light Generator (ILG)
This invention is a practical extension of Stanford docket S05-170 (photosensitive proteins Channelrhodopsins) and describes an implantable, light-generating device for the optical stimulation of neural cells. Essentially an optical electrode, this is intended to be a next-generation method providing deep brain stimulation (DBS). Importantly, this neural interface is designed to permit neuron-type-specific modulation. For example, motor fibers might be recruited while leaving immediately adjacent pain fibers undisturbed or excitatory neurons might be harnessed without affecting inhibitory neurons in a region. Targeted, temporally-precise control of neuronal subtypes may enable neuromodulation with fewer side effects and more robust therapeutic efficacy.
Applications
- Neurostimulation of photosensitive cells
Advantages
- Once implanted, selective activation of the photo-sensitive cells can be achieved non-invasively.
Publications
- US Patent Application: 11/651,422
- Sohal VS, Zhang F, Yizhar O, Deisseroth K. Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature. 2009 Jun 4;459(7247):698-702. Epub 2009 Apr 26.
- Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature. 2009 Jun 4;459(7247):663-7. Epub 2009 Apr 26.
- Tsai HC, Zhang F, Adamantidis A, Stuber GD, Bonci A, de Lecea L, Deisseroth K. Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning. Science. 2009 May 22;324(5930):1080-4. Epub 2009 Apr 23.
- Gradinaru V, Mogri M, Thompson KR, Henderson JM, Deisseroth K. Optical Deconstruction of Parkinsonian Neural Circuitry. Science. 2009 Apr 17;324(5925):354-9. Epub 2009 Mar 19.
- Airan RD, Thompson KR, Fenno LE, Bernstein H, Deisseroth K. Temporally precise in vivo control of intracellular signalling." Nature. 2009 Apr 23;458(7241):1025-9. Epub 2009 Mar 18.
Related Links
Patents
- Published Application: 20080085265
- Published Application: WO2008089003
- Published Application: 20100190229
- Published Application: 20150217128
- Published Application: 20180326221
- Published Application: 20190321651
- Issued: 8,926,959 (USA)
- Issued: 10,052,497 (USA)
- Issued: 10,569,099 (USA)
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