Kinase-modulated bioluminescent indicators for reporting drug activity in vivo

Stanford researchers in the Lin Lab have identified kinase-modulated bioluminescent indicators (KiMBIs) which can assess real time kinase inhibition in target tissues in vivo.

Kinase inhibitors are a highly researched area as therapies for cancer and Parkinson's Disease, as well as other neurological diseases. Existing methods for measurements of kinase activity involve tissue retrieval and biochemical analysis, which require the use of numerous animals and manual dissection, causing this method to be expensive and time-intensive. KiMBIs report kinase inhibition via light production from the luciferase substrate injection, enabling a noninvasive, inexpensive, and real-time assessment of kinase inhibition.

Stanford Medicine 4/11/23 - Bioluminescence helps researchers develop cancer drugs for brain

Stage of Development

• Prototype

Figure:

Figure description: Graphical Abstract

Image credit:https://pubs.acs.org/doi/10.1021/acscentsci.3c00074