Large-scale electrophysiology amplification platform (LEAP)

Stanford researchers have developed the Large-scale Electrophysiology Amplification Platform (LEAP), a wireless, label-free optical system for monitoring the electrical activity of neurons and heart cells. LEAP enables high-resolution, real-time recording without the need for invasive wiring or fluorescent dyes, making it safer and more scalable for both research and clinical applications

Traditional methods for tracking neural and cardiac activity often rely on microelectrode arrays or optical imaging with labeling dyes, both of which have limitations: wiring is cumbersome and hard to scale, while dyes can interfere with natural cell function and are not ideal for human use. LEAP solves these problems by using a nanofabricated photonic chip that detects cellular activity through changes in light reflection, eliminating the need for wires or labels. The compact chip can be easily integrated with standard microscopes and is suitable for use in both laboratory and medical settings.

Stage of Development: Research - in vitro