Method and apparatus for autonomous parameter adaptation of non-invasive multichannel stimulation

The Tass Lab has invented non-invasive, Vibrotactile Coordinated Reset (vCR) stimulation devices and methods to safely and efficiently treat brain disorders characterized by abnormal neuronal synchrony such as Parkinson's disease.

For a more effective vibrotactile therapy, the Tass Lab developed a closed loop, self-tuning algorithm that calibrates and optimizes Coordinated Reset (CR) treatment based on assessments of the patient's symptoms. The invention automatically and autonomously calibrates relevant stimulation parameters (stimulus intensities, stimulation frequency, temporal jitter, amplitude, CR sequences) for non-invasive and invasive multichannel CR stimulation and related stimulation. Parameter adjustment is optimized via a reinforcement learning algorithm with the goal to learn the best-performing stimulation pattern for each assessment outcome based on the history of both assessment outcomes and delivered stimulation patterns. The automatic/autonomous calibration and optimization provide a more effective treatment with better desynchronization effects (symptom relief), sooner and with less treatment time than prior methods.

Stage of Development – Proof of Concept Prototype
Simulations testing the reinforcement learning algorithm is ongoing and will be incorporated in the Vibrotactile Coordinated Reset (vCR) Glove pilot, and FDA approval study.

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