Methods and compositions for treating or preventing narcotic withdrawal symptoms

Researchers at Stanford University have developed a newly patented method for reducing the physiological symptoms of opioid withdrawal by targeting a well-characterized receptor. The inventors have demonstrated the utility of this approach in both a mouse model and an acute morphine administration model in humans. Unlike current treatments for opioid withdrawal, this strategy does not rely on controlled substances or medications with significant hemodynamic side effects. The approach could be applied using either existing FDA-approved compounds or new agents. In addition, by combining this technology with narcotics, new products could be developed that alleviate influences that contribute to the misuse of prescription opioids.

Stage of Research
The inventors have validated the technology in mouse and human models of withdrawal.