Monoclonal Antibody for Hypocretin-1 (MAb 310)

Researchers in Prof. Emmanuel Mignot's laboratory developed a mouse monoclonal antibody to the N-terminal end of the hypocretin-1 protein (Hcrt-1, also known as orexin-A). Hcrt-1 is an excitatory neuropeptide hormone with established effects on wakefulness, mood and lipid metabolism. The absence of hcrt-1 can cause narcolepsy. This antibody has applications for narcolepsy diagnostics and for basic research of sleep disorders and metabolism.