Docket #: S13-149
Neurexin-1alpha knockout mouse model of autism and schizophrenia
Mouse model used to replicate a gene mutation that has been repeatedly observed in autism and schizophrenia patients.
This invention is jointly owned with UT Southerwestern. For licensing information please contact: TechnologyDevelopment@utsouthwestern.edu
Applications
- Can potentially be used for screening for drugs against neuropsychiatric disorders, for validating drug candidates, or for exploring pathogenetic mechanisms involved in neuropsychiatric disorders
Advantages
- Animal models of schizophrenia and autism are notoriously difficult to generate, and this model replicates not only the genetic nature of these conditions, but also mimics some of the symptoms observed in the conditions.
Publications
- PNAS, October 20, 2009, Vol. 106, No. 42 17908-18003
Similar Technologies
-
Dynamic-Contrast-Enhanced Magnetic Resonance Imaging with Flow Encoding S15-257Dynamic-Contrast-Enhanced Magnetic Resonance Imaging with Flow Encoding
-
Brain-machine interfaces for seizure detection leveraging information theory S17-071Brain-machine interfaces for seizure detection leveraging information theory
-
Portable Nystagmus Detection and Monitoring Device for Diagnosis and Management of Vestibular Disorders S18-486Portable Nystagmus Detection and Monitoring Device for Diagnosis and Management of Vestibular Disorders