Novel Protocol For Generation of Cardiac Progenitor Cells and Cardiomyocytes from iPSCs

For the application of human pluripotent stem cell-derived cardiomyocytes in drug discovery, cardiotoxicity testing, disease modeling, and regenerative medicine large numbers of cells need to be derived from a variety of cell lines in a defined, reproducible and cost-efficient manner.

Researchers at Stanford's School of Medicine have developed a technique that enables the differentiation of human pluripotent stem cells to cardiomyocytes with high purity (>85% TNNT2+), efficiency and reproducibility. This technique has been demonstrated to function in a wide variety of hiPSC lines.