Quantification of contrast-enhanced ultrasound parametric maps with a radiomics-based analysis

Volumetric contrast-enhanced ultrasound is a new approach to collect 3D imaging data of a contrast signal. So far, analysis of 3D contrast ultrasound has relied on averaging a set of voxels embedded in an ROI or a VOI. Methods to extract time-intensity curves at each image plane pixel have also been developed for 2D contrast-enhanced ultrasound. We have developed methods to automatically extract time-intensity signal at each voxel in an image and to subsequently generate parametric maps based on specific parameters extracted mathematically from time-intensity curves.