Temporally Precise, Genetically Targeted Optical Control of Neural Circuitry

Applications

• High-throughput cell-based screening for drugs that affect signal transduction
• Neuromodulatory therapeutics for the treatment of neurological disorders
• Drug dosing management in the context of diabetes and pain control

Advantages

• Millisecond kinetics enables a thousand-times faster voltage control
• The expression of the ChR2 channel does not affect membrane integrity and cell health
• This method does not require synthetic chemical substrates
• Allows genetic targeting so that specific neuron subclasses can be probed

Publications

• Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K. Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci. 2005 Sep;8(9):1263-8. Epub 2005 Aug 14.
• Published international patent application no. WO 2007/024391
• Published patent application USSN 11/459,637 no. US-2007-0053996-A1
• Published patent application USSN 11/459,638 no. US-2007-0054319-A1
• Published patent application USSN 11/459,636 no. US-2007-0261127-A1

Related Links

• Deisseroth Lab

Patents

• Published Application: 20070261127
• Published Application: WO2007024391
• Published Application: 20070053996
• Published Application: 20070054319
• Published Application: 20100234273
• Published Application: 20150165227
• Published Application: 20160096036
• Published Application: 20160252524
• Published Application: 20180328944
• Published Application: 20190049462
• Issued: 8,906,360 (USA)
• Issued: 9,278,159 (USA)
• Issued: 10,036,758 (USA)
• Issued: 9,101,690 (USA)
• Issued: 10,094,840 (USA)
• Issued: 9,829,492 (USA)
• Issued: 10,422,803 (USA)
• Issued: 10,627,410 (USA)