Tuning of reversible and irreversible electroporation lesions by manipulating pulse waveforms

Stanford researchers have developed a method that can tune the ratio between reversible (RE) and irreversible (IRE) electroporation through waveform adjustments.
This is accomplished by altering the pulse waveform in such a way that one phenomena dominates over the other. These two phenomena typically overlap and there is no established method for targeting one therapy over the other.
This method also overcomes some challenges with electroporation including the elimination of muscle contractions and production of more predictable ablation volumes in vivo. Applications include improving in vivo gene therapy, delivery of chemotherapeutics, delivery of large molecules across the blood brain barrier, and the ablation of solid tumors.

Stage of Research