Stanford scientists have developed a strategy that enables simultaneous and combinatorial genetic screening across different types of genetic perturbations (gene knockouts, knock-ins, overexpression, and gene domain modification).
To overcome current gene editing safety, efficacy, and scope limitations, Stanford researchers in the Mackall Lab and Stanley Qi Lab developed MEGA (Multiplexed Effector Guide Arrays), a versatile and multifunctional platform for programmable and scalable regulation of the T c
Stanford Medicine's Ji Research Group has developed a simple, quantitative method for detecting and characterizing gene fusions that uses DNA rather than RNA as analyte.
Cell culture is a central technique used for a plethora of research applications including in the modeling of complex diseases, creating transgenic animals, gene therapy, cell therapy, regenerating lost tissue, and organ biogenesis.
Researchers at Stanford University have developed a scalable, single-cell barcoding system and method for genomic editing and tracking using cas12a-based compressive molecular probes.
Stanford inventors have developed the CasKAS method for profiling CRISPR off-targets using single-stranded DNA (ssDNA) mapping. Binding of CRISPR protein to DNA generates ssDNA structures, which can be a sensitive biochemical signal of CRISPR occupancy.
Researchers at Stanford have developed a rapid and efficient method for high-throughput genome editing using CRISPR/Cas9. The CRISPR/Cas9 system allows researchers to edit any site in an organism's genome.
Researchers at Stanford have developed methods for controlling CRISPR-based gene editing and gene regulation. CRISPR systems have been developed for gene editing and gene expression regulation in both prokaryotic and eukaryotic organisms.
Researchers in the Stanford Genome Technology Center have developed a robust, high-throughput, high-efficiency functional genomics platform to generate precisely edited genome variant libraries and then readily isolate and identify thousands of individual strains en masse
Researchers at Stanford have developed methods to overcome the limited packaging capacity of adeno-associated virus (AAV) vectors and enable their use in integration of large transgenes.