Stem cells are generally influenced by a microenvironmental niche, typically comprised of epithelial and mesenchymal cells and extracellular substrates. Many attempts have been made to produce culture systems that mimic normal intestinal epithelial growth and differentiation.
Patients with celiac disease have a pathological reaction to gluten and have either HLA-DQ2+ (90%) or HLA-DQ8+, but expression of these MHC class II haplotypes is not sufficient and other factors are necessary for the development of celiac sprue.
Researchers at Stanford University have formulated a novel biomaterial suitable for three-dimensional (3D) bioprinting: a homogeneous composite of polycaprolactone (PCL), gelatin, and beta-tricalcium phosphate.
Researchers at Stanford have invented a novel hydrogel with enhanced retention and extended durability. This hydrogel can be held together three times longer than many alternatives without sacrificing its self-healing attributes during injection.
Stanford researchers have designed a new 3-dimensional (3D) hydrogel cell culture system that models native tissue environment with precise control over gelation and degradation properties.
Current injectable hydrogel materials have fast erosion and limited tunability of their mechanical properties at different stages of applications, limiting their biomedical applications.
Engineers in Prof. Zhenan Bao's lab have developed highly conductive, stretchable composite hydrogel materials that can be used as soft electrodes that match the mechanical properties of a range of biological tissues.