Researchers in Prof. Karl Deisseroth's laboratory have developed a portfolio of microbial opsin proteins that can be used for precise and modular photosensitization components that enable optical control of specific cellular processes.
Researchers in Prof. Karl Diesseroth's laboratory have discovered a Dopamine receptor type 2 specific promoter (D2SP) that can be used to transfect, identify and isolate Dopamine R2 (D2R)-expressing cells.
Researchers in Dr. Karl Deisseroth's lab have developed a selective approach to treat anxiety. Anxiety is characterized by several features that are coordinately regulated by diverse neuronal system outputs.
The Hong Neurotechnology Lab at Stanford University developed ultrasound-activated nanoscopic light emitters (mechanoluminescent nanoparticles) that are delivered via the blood stream, unlike conventional optogenetics approaches that require invasive fiber optic implants.
Researchers in Prof. Mark Schnitzer's laboratory have developed a two-photon scanning microscope for imaging neural activity in a 2x2mm field of view while maintaining a fast scanning rate (~10Hz image update frequency).
Stanford researchers have developed a wirelessly powered, fully internal implant which allows for optogenetic control of neurons throughout the nervous system in mammals, and in particular, mice.
Researchers in Prof. Karl Deisseroth's laboratory have developed a highly precise, scalable optical system for imaging or controlling thousands of individual neurons in the 3D volume accessible with a single multiphoton fluorescent microscope objective.
Researchers in Prof. Karl Deisseroth's laboratory have developed an optical imaging and optogenetics two photon laser system that uses a single beam to illuminate many sites in three-dimensions.
Researchers in Prof. Karl Deisseroth's laboratory have engineered versatile, virus-based constructs that are driven by neuronal activity to either label or optogenetically control those active neurons.
Researchers in Dr. Karl Deisseroth's lab have engineered a channelrhodopsin variant that can be stimulated by red light and has fast stimulation frequencies. In neurons, channelrhodopsins are light activated protein channels that induce action potential firing.
To better understand how the brain processes information and generates behavior, researchers in Dr. Liqun Luo's lab have generated the FosTRAP and ArcTRAP mouse strains.
Researchers in Dr. Karl Deisseroth's lab have created inhibitory channelrhodopsins (ChRs) that allow fast, reversible inhibition of electrical signals in neurons. Optogenetics is a technique used to understand normal and pathological neural circuitry.
Researchers in Prof. Karl Deisseroth's laboratory have developed specific, inducible animal models for depression that use targeted optogenetic strategies to precisely dissect the neuronal circuits underlying the condition.
Researchers in Prof. Robert Malenka's laboratory have developed a light-activated animal system that could be used to identify compounds that treat certain psychiatric disorders.
Researchers in Prof. Karl Deisseroth's laboratory have developed a system to enhance optogenetic pumps using one tool to address current limitations in both inhibition and excitation.