Notice: Undefined index: HTTP_ACCEPT_LANGUAGE in C:\inetpub\wwwroot\technology_detail.php on line 331
 Technology Detail


The Office of Technology Licensing was established in 1970 to transfer technologies developed at Stanford. Find out more about OTL's history, mission, staff, and statistics.

Login to TechFinder » 

Reporter cell line for TGFbeta signaling


Stanford Reference:

07-069


Abstract


Stanford researchers have developed a cell line (MFB-F11) that can be used for an easy, sensitive, and specific bioassay to study the biological functions of Transforming Growth Factor-beta (TGF-beta). TGF-beta regulates key biological processes and has been implicated in many diseases. The MBF-F11 cells can be used for basic research or for screening drugs that target the TGF-beta signaling pathway. In addition, assays can be performed on a variety of biological samples, including cell culture supernatants, body fluids, or tissue homogenates, with or without prior denaturation of TGF-beta.

Applications


  • Drug screening - for compounds that target the TGF-beta signaling pathway
  • Research - basic research on the effects of TGF-beta on biological processes

Advantages


  • Rapid
  • Sensitive - assay detected as little as 1pg/ml TGF-beta1
  • Specific - MFB-F11 cells were highly induced by TGF-beta, TGFbeta2 and TGF-beta3, but did not show induction with related family members or trophic factors
  • Simple - MFB-F11 cells can detect and quantify TGF-beta from biological specimens with or without prior denaturation of TGF-beta

Publications



Web Site


Wyss-Coray Lab

Related Web Links



Innovators & Portfolio



Date Released

 6/30/2015
 

Notice: Undefined offset: 0 in C:\inetpub\wwwroot\technology_detail.php on line 1350

Licensing Contact


Brenda Martino, Biological Materials Specialist
(650) 725-9119 (Direct)
Request Info

[-] Map/Timeline

78-017 Monoclonal Antibodies: 11-6 anti-Ig-5b, 11-5 anti-I-A (2), 11-4 anti-H-2Kk, 11-3 anti-I-A917), 10-4 anti-Ig-5a, H-12 anti-THY 1.2
79-066 Mouse Anti-Human Hybridomas L243, L17F15
82-008 A Monoclonal Antibody Specific For Mouse Granulocytes

more technologies »

Related Keywords


alzheimer's disease   atherosclerosis   blood   cancer   cardiovascular   immune   infectious   neurological diseases   rheumatoid arthritis   stroke   fibrosis   research tool: cell line   screening: cellular assay   screening: screen   signaling pathways   research tool   screening   
 

   

  

Also of Interest...
78-017 Monoclonal Antibodies: 11-6 anti-Ig-5b, 11-5 anti-I-A (2), 11-4 anti-H-2Kk, 11-3 anti-I-A917), 10-4 anti-Ig-5a, H-12 anti-THY 1.2
79-066 Mouse Anti-Human Hybridomas L243, L17F15
82-008 A Monoclonal Antibody Specific For Mouse Granulocytes

Recently Viewed...
S07-069 Reporter cell line for TGFbeta signaling