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Dissolving Microneedles for Allergen Skin testing and immunotherapy


Stanford Reference:

11-420


Abstract


Stanford researchers have developed a microneedle-based technology that can deliver multiple, intact proteins or peptides to the skin for allergen skin testing and immunotherapy. When applied to testing linear epitopes of food allergens, this approach offers advantages for easy, low-cost, and functional testing of thousands of epitopes in parallel. Furthermore, this approach also tests not only for the risk of reaction but also for the severity of the reaction. For immunotherapy, dissolvable needles can allow persistence of antigen over days or weeks, enabling improved desensitization to the allergen.

The proposed product comprises pre-packaged microneedle arrays specific for individual foods (e.g., peanut or egg) or for a panel of highly allergenic foods (e.g., all nuts, fish and shellfish). The product would include a reusable infrared camera to image the thermal responses of the skin test, plus onboard software to interpret and output the results in an electronic, printable format.

Figure

Figure description - Microscopic images of labeled allergen microneedles. (A) Microneedles incorporated with rhodamine-labeled peanut protein (left), fluorescein isothiocyanate-labeled casein protein (middle) and DQ ovalbumin (right). (B) The dimensions of microneedles are shown, consistent with the PDMS mold

Stage of Research

• Developed and tested polyvinylpyrrolidone (PVP) microneedles and measured the delivery of proteins into skin
• Showed that this method of fabrication preserves the protein conformation
• These microneedles can serve as a platform for delivering protein antigens and therapeutic proteins to the skin for allergen skin testing or immunotherapy


Applications


  • Allergy skin testing - Improved skin prick testing (SPT) for allergic responses to foods, environmental allergens, occupational allergens, pet allergens, stinging insects, and allergenic drugs
  • Predicts severity of reaction, not just the likelihood of reaction as does the current SPT
  • Immunotherapy - Dissolvable needles can allow persistence of antigen over days or weeks, depending on the formulation of the polymer, enabling improved desensitization to the allergen

Advantages


  • Fast and simple
  • Inexpensive
  • Comprehensive allergy testing
  • Measure both the risk of reaction as well as the severity of reaction
  • Both as diagnostic and therapeutic device
  • Overcomes the shortcomings of current allergen testing and offers the advantages of both SPT (i.e., easy, low cost, and functional testing) and array-based IgE testing (i.e., parallelization)

Publications



Innovators & Portfolio



Patent Status



Date Released

 3/24/2016
 

Licensing Contact


Irit Gal, Senior Licensing Associate
650-723-1586 (Business)
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Related Keywords


Food Allergies   11-420   healthcare: microarrays   screening: screen   allergy   medical devices: drug delivery   screening: detection   diagnostic: immunoassay   immunotherapy   microneedles   Allergic immune system   allergy testing   allergy treatment   healthcare: diagnostic tool   peptide drug delivery   protein drug delivery   subcutaneous drug delivery   therapeutic: drug delivery   Transdermal Drug Delivery   healthcare: syringe/needles   proteins and peptides   farmteamNO   
 

   

  

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