Notice: Undefined index: HTTP_ACCEPT_LANGUAGE in C:\inetpub\wwwroot\technology_detail.php on line 331
 Technology Detail


The Office of Technology Licensing was established in 1970 to transfer technologies developed at Stanford. Find out more about OTL's history, mission, staff, and statistics.

Login to TechFinder » 

Synthesis of uniformly-sized, water-soluble gold nanoparticles


Stanford Reference:

16-086


Abstract


Researchers in Prof. Roger Kornberg’s laboratory have developed a high-yield, controlled technique to synthesize water-soluble, thiolate-protected gold nanoparticles of homogeneous size without a purification step. The size of the nanoparticles is controlled by the gold:thiol ratio and its uniformity by an equilibration step during synthesis. Because the resulting nanoparticles are a homogeneous size, they minimize variability in downstream applications. For example, point-of-care immunoassays are more reliable and reproducible which thereby lowers costs. The gold nanoparticles could be conjugated to a variety of biological molecules with a range of applications in diagnostics, imaging and drug delivery.

We are asking parties interested in commercializing this technology to please contact Stanford OTL by Friday, Sept. 30, 2016.

Stage of Research
The inventors have established the synthetic protocol and demonstrated how the resulting nanoparticles react with protein and DNA.


Applications


  • Synthesis of gold nanoparticles with end-user applications such as:
    • diagnostics – detection for in vitro point-of-care immunoassays
    • tumor targeting
    • imaging agents
    • therapeutic drug delivery

Advantages


  • Tunable, homogeneous size:
    • nanoparticles have uniform, controlled size with no purification step
    • improves optical properties and reliability of assays
  • Water soluble:
    • suitable for conjugation to biological molecules for diagnostic and therapeutic applications
    • choice of thiol determines reactivity
  • Low-cost, high yield synthesis:
    • over 90% yield minimizes waste of expensive gold reagent
    • no labor-intensive purification step

Publications



Innovators & Portfolio


  • Maia Azubel   
  • Roger Kornberg   

Date Released

 7/25/2016
 

Licensing Contact


Anne Kopf-Sill, Licensing Associate
(650)498-8015 (Business)
Login to Request Information

[-] Map/Timeline

02-123 Detection of Protein Modification
02-179 Diagnosis of CML and other leukemias using beta-catenin biomarker
02-288 Measurement of Metallic Film Thickness Using a New Optical Technique

more technologies »

Related Keywords


absorption enhancer   cancer drug delivery   drug delivery   drug encapsulation   gold nanoparticles   metal nanoparticle   nanoparticle synthesis   nanoparticles drug delivery   SERS detection   tumor imaging   tumor targeting   diagnostic: detection   lateral flow assay   diagnostic: point of use   diagnostic: point-of-care   
 

   

  

Also of Interest...
02-123 Detection of Protein Modification
02-179 Diagnosis of CML and other leukemias using beta-catenin biomarker
02-288 Measurement of Metallic Film Thickness Using a New Optical Technique

Recently Viewed...
S16-086 Synthesis of uniformly-sized