Monoclonal Antibody MB-1 (CD37)

Prof. Ron Levy's laboratory at Stanford developed a monoclonal antibody and hybridoma that targets CD37 (formerly known as MB-1). CD37 is expressed by mature human B cells in blood and tonsil, but not on T cells, thymocytes, granulocytes, or platelets. Initial studies of malignant B cell tumors revealed that the antigen is expressed by virtually all Ig-expressing B cell tumors but only 10% of SIg B-lineage leukemias.