Novel compounds inhibit phospholipid synthesis in cancer

Disease indication
Cancer: Renal cell carcinoma (RCC), hepatocellular carcinoma (HCC)

Drug format: Small molecule compounds, alone or in combination with other chemotherapeutic drugs

Drug class: First-in-class

Target: Enzymes in phospholipid metabolic pathway

Research stage and Preliminary data
The inventors demonstrated that various lipogenesis inhibitors suppress cancer proliferation in RCC and HCC lines.

Continued research: The inventors continue to develop SAR for development candidate.

Background: Previous studies have shown that lipid metabolism is frequently perturbed in cancers. Using desorption electrospray mass spectrometry (DESI-MSI), the inventors showed that phospholipid metabolism is altered.

Mode of action: Inhibiting phospholipid metabolism disrupts cancer metabolism, suppressing cancer proliferation. To date, the inventors have demonstrated results for HCC and RCC.