S20-218 First-in-class isoform-specific aldehyde dehydrogenase (ALDH1B1 and ALDH1A3) inhibitors for cancer Every year, 1.4 million new cases are reported for colorectal cancer but existing treatments are not effective. This represents an estimated $1 billion market annually in the US. James Chen Toni Kline Alison Ondrus Cody Marshall Marisa Hom Zhiping Feng
S19-257 Novel compounds inhibit phospholipid synthesis in cancer Disease indication Cancer: Renal cell carcinoma (RCC), hepatocellular carcinoma (HCC) Drug format: Small molecule compounds, alone or in combination with other chemotherapeutic drugs Drug class: First-in-class Arvin Gouw Steven Schow Robert Greenhouse Toni Kline Dean Felsher