Rapid, portable blood ammonia detection device (PAD)

Stanford researchers in the Kanan Lab have patented a low-cost, portable, and easy-to-use device designed to rapidly detect elevated ammonia levels from a drop of blood. This device can help manage treatment for patients with conditions like urea cycle defects and liver disease, or those undergoing certain chemotherapy treatments. With easy detection, patients can be treated to prevent cognitive impairment and other effects of hyperammonemia.

The device uses a fuel cell component to measure ammonia released from whole blood upon alkalinization, achieving the same sensitivity and accuracy as traditional lab assays but with a smaller blood sample that requires no special handling. It is suitable for point-of-care analysis at the bedside or in a patient's home, with applications in diagnostics, patient monitoring, and drug development.

Stage of Research
The inventors have tested a prototype Portable Ammonemia Detector (PAD) using 100 microliters (2 drops) of blood. The results were highly correlated with conventional plasma ammonia testing (r² = 0.97) across a range of ammonia concentrations seen in clinical practice.