Solving brain circuit function and dysfunction with computational modeling and optogenetic fMRI

Stanford researchers at the Lee Lab have developed a method to understand whole-brain circuit mechanisms underlying neurological disease and its application to predict the outcome of therapeutic interventions.

By combining optogenetic fMRI with computational modeling, cell type-specific, large-scale brain circuit function and dysfunction are now starting to be quantitatively parameterized. These new findings can pave the path for future therapeutics developments based on a systems engineering approach aimed at directly restoring brain function.

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Figure description: Graphical Abstract

Image credit: https://doi.org/10.1016/j.celrep.2022.111631

Stage of Development