Temporally precise, noninvasive control of neural circuitry is a long-sought goal of neuroscientists and biomedical engineers. Stanford University researchers in the laboratory of Dr.
Researchers in the laboratories of Dr. Karl Deisseroth and Dr. Peter Hegemann have engineered mutant ChR2 (Channelrhodopsin-2) proteins with light-sensitivity that is increased by orders of magnitude compared to wild-type ChR2.
Researchers in Prof. Karl Deisseroth's lab have discovered and engineered new microbial opsin proteins and cell trafficking tools to enable selective cell-type specific, light-sensitive switches for neuromodulation.
Researchers at Stanford have discovered a powerful new optogenetic actuator- a novel red-shifted opsin. Optogenetics is a technique used to study function and communication between cells.
Stanford researchers have developed a wirelessly powered, fully internal implant which allows for optogenetic control of neurons throughout the nervous system in mammals, and in particular, mice.
Dr. Karl Deisseroth and Dr. Raju Tomer have developed a CLARITY optimized light-sheet microscope (COLM) for rapid, high-resolution imaging of large intact tissue samples.
Researchers in Prof. Karl Deisseroth's laboratory have developed a highly precise, scalable optical system for imaging or controlling thousands of individual neurons in the 3D volume accessible with a single multiphoton fluorescent microscope objective.
Researchers in Prof. Karl Deisseroth's laboratory have engineered a cytosolic, red genetically encoded calcium indicator (GECI) with high signal change at single cell resolution.