Chronic stimulation of CD8+ T cells lead to a state of dysfunction known as exhaustion. Yet, there is a subset of functional CD8+ T cells defined by SIRP? expression. These are capable of proliferating, secreting IFN?, and exhibiting cytolytic activity.
Stanford researchers have developed a strategy to manipulate the architecture of coronary arteries by upregulating the transcription factor Dach1 in endothelial cells.
Encapsulation of therapeutic cells can increase its efficacy, but current methods are non-uniform and inefficient. This inconsistency leads to varying interactions between each encapsulated cell and the extracellular matrix (ECM).
Radiation therapy is a common option in diseases like breast cancer, but can also cause significant damage to the skin. Permanent scarring and fibrosis can result, with both aesthetic and functional consequences for cancer patients.
Researchers in the Cui lab have designed a polymer-polymer solid-state electrolyte for lithium batteries that is fireproof, lightweight, and mechanically robust.
Stanford researchers have developed CheXpert which can reduce noise and identify several pathologies on x-rays with very high accuracy via machine learning. CheXpert can read photos of x-rays from a mobile phone and is robust to noise.
Researchers at Stanford University, Technical University of Denmark, and Norwegian University of Science and Technology have developed a software suite that can predict long-term performance of reinforced concrete based on multiple, fundamental, physics phenomenon like humidit
Stanford researchers have targeted Wnt11 to reduce capsular fibrosis around implants. Fibrosis commonly occurs following surgical implantation of devices resulting in pain, discomfort, and implant damage.
Stanford researchers have integrated concrete durability modeling software into building information models (BIM) for better management, repair, and assessment of structural elements like roads, bridges, dams, buildings, etc.
Neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have been characterized by the expansion of the GGGGCC hexanucleotide repeat within the non-coding region of the human chromosome 9 open reading frame 72 (C9ORF72) gene.
Stanford researchers have designed a trainable portable device that can rapidly quantify liver steatosis (fat) prior to transplantation without a pathologist. Currently, rapid assessments are hindered by waiting for an available pathologist to provide results.
Stanford researchers have developed a crowdsourced framework for real-time robotic teleoperation with six degrees of freedom. Through smartphone controllers, RoboTurk enables large human workforces to remotely operate the robots without the need for prior training.