Stanford scientists have discovered that treatment with the metabolite N-acetyltaurine leads to weight loss. They found that the removal of PTER, a key enzyme that regulates N-acetyltaurine metabolism, leads to N-acetyltaurine accumulation and a reduction in food intake.
Stanford researchers have identified exercise-inducible, carboxylesterase 2 (CES2) proteins, which suppress obesity in high fat diet-fed mouse models. Generally, CES2 proteins are intracellular and localized to the endoplasmic reticulum.
Stanford and Baylor researchers have discovered an exercise-induced lactate-derived metabolite that mediates the anorexigenic and anti-obesity effects of physical activity.