Anti-mouse endoglin MAb MJ7/18.
A rat IgG2A MAb recognizing mouse endoglin. In the mouse, endoglin serves as a specific endothelial cell differentiation antigen. Endoglin has been implicated as TGFb3-binding molecule.
This antibody(MEL-14) is specific for a single class of lymphocyte surface molecules that appear to mediate recognition of lymph node high endothelial venules and that appear to be required for lymphocyte homing to lymph nodes in vivo.
This invention consists of mouse L1/2 pre B cells and human Jurkat cells transfected with serpentine receptors. These cell lines have been shown to be induced by specific ligands to activate lymphoid cell integrins and hence cell adhesion.