The Stanford Sarafan ChEM-H Medicinal Chemistry Knowledge Center has developed a novel aqueous solubilizing promoiety (Sol-moiety) that can be readily attached to a wide-range of functional groups and undergo controlled cleavage to improve the pharmacokinetic profile of a desi
Researchers at Stanford and the University of Helsinki discovered that a human secretoglobin protein found in sweat gland cells acts as a novel host defense mechanism against Lyme disease.
Stanford scientists in Chris Garcia's lab have developed leptin analogs that have potentially more favorable pharmacokinetic and pharmacological signaling properties for use as diabetes and obesity drugs.
Stanford researchers have developed a method to eliminate antibiotic resistant gram-negative bacteria in the growth arrest phase. The increase in relapsing bacterial infections and the rise of drug resistant bacteria are significant global health problems.
Wound healing is a huge clinical problem. Problematic outcomes of skin wounds can range from under-healing (e.g., chronic/non-healing wounds) to over-healing (e.g., scarring).
Stanford scientists have developed broadly neutralizing antibodies against sarbecoviruses , including SARS-CoV-2 related Clade 1b, SARS-CoV related Clade 1a and Clade 3 viruses, paving the way for future vaccines and therapeutics.
Researchers at Stanford University have developed a novel method for the first time to generate cardiac pericytes from human induced pluripotent stem cells that closely resemble primary cells.
Stanford researchers have developed a method to target and lower alpha-synuclein, a major protein constituent of Lewy bodies that accumulate in the brain in Parkinson's disease, using viral gene transfer of mutant Cas9 coupled with a small guide RNA targeting the promoter regi
Stanford scientists developed a novel strategy that uses resting-state functional connectivity magnetic resonance imaging (rs-fMRI) to determine whether a person will respond to treatment for depression.
Researchers at Stanford and UCSF have discovered a strong association between serious, potentially fatal, delayed hypersensitivity reactions that occur in a subset of patients exposed to IL-1/IL-6 inhibitors and HLA-DRB1*15 alleles that are common across ancestries.
Stanford researchers at Dr. Williams' Brain Stimulation Lab have developed a method to treat brain disorders such as traumatic brain injury using a naturally occurring psychoactive molecule found in plants called Ibogaine.