Engineering novel proteins through directed evolution have become a foundation of protein engineering in biotech. However, these techniques are incapable of simultaneous engineering of protein-protein pairs through library-on-library selections.
Many applications in cell therapy, synthetic biology, and gene therapy require extensive cell engineering, often with multiple vectors due to limitations in packaging capacity.
Researchers at Stanford have created ligand-induced dimerization activating RNA editing (LIDAR), a versatile molecular sensor that turns the presence of a ligand into translation of an output protein.
Stanford researchers have found a solution to enhance mRNA translation and stability by harnessing SARS-CoV2 genomic sequences themselves. They discovered that the SARS-CoV2 5' untranslated region (5' UTR) can be repurposed for increased translation and stability of any mRNA.
Stanford researchers have developed one of the smallest, active translational enhancers that can be adapted to control gene regulation. The translation enhancer is a short RNA stem-loop structure isolated from a Hox gene.