The inventors have identified and developed an archaeal light-driven chloride pump (NpHR) from Natronomonas pharaonis for temporally precise optical inhibition of neural activity. NpHR allows either knockout of single action potentials, or sustained blockade of spiking.
Ion channel dysfunctions lead to a wide array of illnesses including epilepsy, cardiac arrhythmia and type II diabetes. However, the number of clinically approved drugs for restoring normal ion channel function is limited.
Researchers in Dr. Karl Deisseroth's laboratory have developed a novel method to rapidly identify neurophysiological measures associated with psychiatric disease and then use those correlates to screen for therapeutics.
Researchers from Prof. Karl Deisseroth's laboratory have developed techniques for specifically modulating the activity of excitable cells in vivo. This approach introduces light-responsive proteins to create photo-sensitive cells.
Researchers in Prof. Karl Deisseroth's laboratory have developed a portfolio of microbial opsin proteins that can be used for precise and modular photosensitization components that enable optical control of specific cellular processes.
Researchers in Dr. Karl Deisseroth's lab have developed a selective approach to treat anxiety. Anxiety is characterized by several features that are coordinately regulated by diverse neuronal system outputs.
Researchers in Prof. Karl Diesseroth's laboratory have discovered a Dopamine receptor type 2 specific promoter (D2SP) that can be used to transfect, identify and isolate Dopamine R2 (D2R)-expressing cells.
Researchers in Prof. Karl Deisseroth's laboratory have used optogenetic tools to develop an animal model for social dysfunction by precisely targeting defined neural circuit elements.
Researchers in Prof. Karl Deisseroth's laboratory have used optogenetic tools to develop an animal model for anxiety by precisely identifying, creating, resolving, and targeting defined neural circuit elements.
Researchers in Prof. Karl Deisseroth's laboratory have combined optogenetics with functional magnetic resonance imaging (fMRI) to enable highly specific in vivo analysis of brain circuits.
Researchers in Prof. Karl Deisseroth's laboratory have used optogenetic tools to develop an animal model for cocaine-modulated behavior modification by precisely targeting defined neural circuit elements.
Researchers in Prof. Karl Deisseroth's laboratory have engineered a novel channelrhodopsin with enhanced expression, faster speed, and improved targeting.
Researchers in Prof. Karl Deisseroth's laboratory have used optogenetic tools to develop a precise, specific and inexpensive animal model of impaired memory.
Researchers in Prof. Karl Deisseroth's laboratory have identified a unifying endophenotype for psychosis that could be used to develop antipsychotic treatments.