Researchers in Dr. Shatz's lab have identified murine PirB and its human ortholog LilrB2 as receptors for β-amyloid (Aβ) oligomers. Aβ oligomers play a central role in a number of pathologies.
The transplantation of retinal pigment epithelial cells (RPEs) or iris pigment epithelial cells (IPEs) to rescue diseased photoreceptors in the subretinal space is one of the leading experimental therapies for Age-Related Macular Degeneration, the most common form of blindness
Stanford and Rockefeller researchers have identified and developed dynein-specific inhibitors that have significant medical applications involving mitotic spindle assembly, organelle transport, and primary cilia formation.