This mouse model of phosphodiesterase deficiency was developed using homologous recombination to knock-out the gene for PDE4B. The mice have a null PDE4B gene on C57BL/6 x 129/OLA background.
The Nolan laboratory has created second-generation retrovirus producer lines, termed Phoenix, for the generation of helper free ecotropic and amphotropic retroviruses.
The FELIX vector system, like the PHOENIX MLV-based packaging system, produces high-titre retroviral particles capable of stably transducing a wide variety of target cells with a gene of interest.
Myers, et al previously discovered that specific loss-of-function mutations in the human cystatin B gene on chromosome 21 cause the human genetic disease Progressive Myoclonus Epilepsy (EPM1).
Adrenergic receptors are plasma membrane proteins that mediate cellular responses to the hormone/neurotransmitters adrenaline and nonadrenaline which are released from sympathetic nerve terminals or the adrenal gland.
Adrenergic receptors are plasma membrane proteins that mediate cellular responses to the hormone/neurotransmitters adrenaline and nonadrenaline which are released from sympathetic nerve terminals or the adrenal gland.
Adrenergic receptors are plasma membrane proteins that mediate cellular responses to the hormone/neurotransmitters adrenaline and nonadrenaline which are released from sympathetic nerve terminals or the adrenal gland.
There are two aspects to this invention, the RetroTet-ART vectors themselves, and the use of those vectors to identify novel regulatory elements (untranslated regions, or UTR's).
LS722 is a rat IgG monoclonal antibody shown to recongnize mouse b7. The antibody has been found to enhance a4b7-mediated lymphoid cell binding to a4 integrin substrates.
Hybridoma cells for the production of monoclonal antibodies against C-terminal fragment of fly patched were made by fusion of spleen cells from an immune mouse and sp2/0 myeloma cells.
Eat1 and Eat2 are monoclonal antibodies (mAbs) which specifically recognize mouse CD81. It is shown that Eat1 binds to the large extracellular loop (EC2), while Eat2 requires the presence of both extracellular loops for binding.