Researchers in Dr. Karl Deisseroth's lab have developed a selective approach to treat anxiety. Anxiety is characterized by several features that are coordinately regulated by diverse neuronal system outputs.
The inventors have identified and developed an archaeal light-driven chloride pump (NpHR) from Natronomonas pharaonis for temporally precise optical inhibition of neural activity. NpHR allows either knockout of single action potentials, or sustained blockade of spiking.
Ion channel dysfunctions lead to a wide array of illnesses including epilepsy, cardiac arrhythmia and type II diabetes. However, the number of clinically approved drugs for restoring normal ion channel function is limited.
Researchers in Dr. Karl Deisseroth's laboratory have developed a novel method to rapidly identify neurophysiological measures associated with psychiatric disease and then use those correlates to screen for therapeutics.
Researchers from Prof. Karl Deisseroth's laboratory have developed techniques for specifically modulating the activity of excitable cells in vivo. This approach introduces light-responsive proteins to create photo-sensitive cells.
Researchers in the laboratories of Dr. Karl Deisseroth and Dr. Peter Hegemann have engineered mutant ChR2 (Channelrhodopsin-2) proteins with light-sensitivity that is increased by orders of magnitude compared to wild-type ChR2.
Researchers in Prof. Karl Deisseroth's lab have discovered and engineered new microbial opsin proteins and cell trafficking tools to enable selective cell-type specific, light-sensitive switches for neuromodulation.
The Dionne lab has developed ultrathin and compact devices for electrically driven beamsteering that fit on a semiconductor chip. These devices rely on resonant dielectric nanostructured surfaces known as "high quality factor" (high-Q) metasurfaces.
Researchers at Stanford have identified polymorphisms in SIRPalpha that can be used to predict responsiveness to immunotherapy. Cancer cells can evade elimination by the immune system by expressing the CD47 "don't eat me" signal.
Stanford researchers at the Taylor Lab have developed software subroutines that can be used together with the open source software system Simvascular to improve the simulation of blood flow in modeling coronary arteries.
Developed at the Taylor Lab, Simvascular is an open source software package encompassing an entire cardiovascular modeling and simulation pipeline from image segmentation, three-dimensional (3D) solid modeling, and mesh generation, to
Stanford researchers have developed a simple optical device for low-power, active light tuning. The device tunes the color of light across the visible spectrum and at select wavelengths by electrical biasing an array of micron sized pixels or nanowires.