Researchers at Stanford have discovered new, chemically distinct opioid receptor ligands that may be used to develop safer opioid therapeutics. Opioids are ligands that bind to the mu, delta, and/or kappa opioid receptors.
Disease indication - HIV infection, specifically reversal of viral latency alone or in combination with other latency reversal agents to improve reservoir targeting.
Engineers in Prof. Zhenan Bao's lab have developed highly conductive, stretchable composite hydrogel materials that can be used as soft electrodes that match the mechanical properties of a range of biological tissues.
Stanford researchers have patented a hydrogel system which allows for the easy encapsulation of cells and biomolecules without requiring external changes in environmental conditions or exposure to chemical crosslinkers.
Researchers at Stanford and their colleagues have developed easily expressed Wnt agonist and antagonists. Wnts are central mediators of development as they influence cell proliferation, differentiation and migration.
Stanford researchers have developed an improved method of distinguishing live and dead cells using mass cytometry, a next-generation form of flow cytometry.
Running chemotherapeutic drug screens on tumor biopsies ex vivo has the potential to increase patient survival by personally matching them to the drug which is the most effective against their particular tumor.
Researchers in Prof. Mark Schnitzer's laboratory have developed a two-photon scanning microscope for imaging neural activity in a 2x2mm field of view while maintaining a fast scanning rate (~10Hz image update frequency).
Researchers at Stanford have developed a simplified LC-MS/MS metabolomics analysis method that requires only a single injection to analyze both polar and non-polar molecules with high resolution of isomeric compounds.
Stanford researchers at the Swartz Research Group have engineered an Iron-Iron (Fe-Fe) hydrogenase with as high as 5-fold enhancement in O2 tolerance by introducing cysteine mutations around the electron supply pathway within the enzyme.
Stanford researchers successfully manufactured high quality optical components using commercially available 3D printing. The 3D printed optics were easy to fabricate and inexpensive.
Stanford researchers have developed a lanthanide-doped upconverting nanoparticle (UCNP) that emits very photostable and non-blinking light, and is bright enough to delineate tumor boundaries to the naked eye during surgery.
Researchers in Prof. Julia Salzman's laboratory have developed an efficient statistically driven tool to improve the accuracy of biomolecules in samples that have a wide range of concentrations.
Researchers in Prof. Juan Santiago's laboratory have developed a technique to rapidly preconcentrate and capture biological targets with high specificity and efficiency. The process can be used to reduce reaction times for microarray analyses and affinity chromatography.
Engineers in Prof. Amin Arababian's laboratory have developed a microfluidics system for ultra high-throughput, low-cost, label-free cell detection in liquid biopsies, fetal cell analysis and other applications.