S10-001 LNK mutations in myeloproliferative neoplasms A team of Stanford researchers has identified mutations in the LNK gene in a subset of patients with chronic myeloproliferative neoplasms (MPNs). LNK (also known as SH2B3) is an adaptor protein that inhibits JAK-STAT signaling. Garry Nolan James Zehnder Stephen Oh Jason Gotlib