Stanford inventors have developed a method to create spatially micropatterned vascularized structures that enable in vitro representation of human and animal biology in models such as cells, tissues, organs, and organoids.
Antimicrobial peptoids are promising leads for novel antibiotics; however, their activity is often compromised under physiological conditions. Inventors at Stanford enhanced the efficacy of antimicrobial peptoids by using thiourea and thiourea derivatives.
Stanford inventors have developed the CasKAS method for profiling CRISPR off-targets using single-stranded DNA (ssDNA) mapping. Binding of CRISPR protein to DNA generates ssDNA structures, which can be a sensitive biochemical signal of CRISPR occupancy.
Stanford inventors have developed a near infrared (NIR) tumor imaging platform that couples a novel rare earth cancer targeting agent and a handheld NIR-IIb fluorescence imager to enable tumor resection down to the few-cell level.
IPEX syndrome is a severe autoimmune disease with limited treatment options caused by mutations in the forkhead box protein 3 (FOXP3) gene, which plays a critical role in immune regulation.
Stanford researchers in the Mahajan Lab have created a customizable proteomics platform that can identify protein biomarkers to differentiate among ischemic eye diseases and identify novel therapeutic targets to treat them.
Researchers at Stanford have developed a rapid and efficient method for high-throughput genome editing using CRISPR/Cas9. The CRISPR/Cas9 system allows researchers to edit any site in an organism's genome.
Researchers at Stanford have developed a probe, NIRDye812, which improves contrast between healthy and diseased tissues for fluorescence-guided cancer surgery applications.
Bioengineers in Prof. Stephen Quake's laboratory have developed an energy efficient, on-chip valve system for automated, multiplexed fluid control in a portable, low-cost microfluidics devices.
Researchers at Stanford have developed a magnetophoretic separation device (MSD) for isolating basophils and other rare cell types from a blood sample. The device applies exponentially increasing magnetic field strength to flowing magnetically tagged cells.
Inventors at Stanford developed a method to leverage mass cytometry, a type of flow cytometry utilizing mass spectrometry, for the detection of heavy metals in leukocytes from individuals exposed to heavy metals in elevated air pollution.