S20-218 Targeting Cancer Stem Cell Metabolism via Isoform-specific ALDH1B1 and ALDH1A3 Inhibitors Colorectal cancer affects 1.4 million new patients annually, with existing treatments often ineffective. A key factor in treatment resistance is high aldehyde dehydrogenase activity, which undermines several chemotherapies. James Chen Toni Kline Alison Ondrus Cody Marshall Marisa Hom Zhiping Feng