S24-196 Targeting Muscarinic Receptors CHRM1 and CHRM3 for Diffuse Midline Glioma Therapy High-grade gliomas, including glioblastoma and diffuse midline glioma are the most common malignant brain tumor types and leading causes of brain-tumor-related death in adults and children, respectively. Michelle Monje-Deisseroth Karl Deisseroth Avishai Gavish Richard Drexler Antonia Drinnenberg