Old age is attributed to over fifty percent of the global disease burden. While aging is a sign of normal development early in life, it leads to the loss of youthful traits and bodily function in later years.
Stanford researchers have patented a system for precise genetic modification of human embryonic stem cells (ECSs) and induced pluripotent stem cells (iPSCs).
Type 1 regulatory T cells (Tr1s) are an inducible subtype of regulatory T cells that can play a beneficial (autoimmune diseases, allergy, hematological malignancies) or detrimental role (some solid tumors and infectious diseases) in human diseases. Tr1 cells.
Researchers at Stanford have created human induced pluripotent stem cells (hiPSCs) derived from adult human dermal fibroblasts exposed to an environmental factor.
Cell culture is a central technique used for a plethora of research applications including in the modeling of complex diseases, creating transgenic animals, gene therapy, cell therapy, regenerating lost tissue, and organ biogenesis.
Researchers in Prof. Gerald Crabtree's laboratory have produced a mouse allowing high-throughput screening for activity and inhibition of virtually any chromatin modifier in any murine tissue.
Stanford researchers have developed an R-spondin1-producing cell line. The cell line is a transfectant of 293T cells expressing mouse R-spondin1 protein tagged with N-terminus HA and C-terminus Fc.
Stanford researchers have developed a cell line (MFB-F11) that can be used for an easy, sensitive, and specific bioassay to study the biological functions of Transforming Growth Factor-beta (TGF-beta).
Researchers in Dr. Dean Felsher's lab have generated a murine hepatocellular carcinoma (HCC) cell line with controllable MYC expression. HCC is one of the most common and incurable malignancies.
This antibody is directed against the human LMO2 antigen, which is expressed as a transcription factor in certain lymphomas and leukemias. We have recently shown that it identifies those lymphomas derived from germinal center B cells.
Researchers in Dr. Shoshana Levy's lab have created a pro B cell lines that provides the first B cell lineage tumors in a C57BL mouse strain. The cell lines, known as H11 and 2F3, were made by transducing mouse bone marrow with BCR-ABL retrovirus.