Researchers in Prof. Karl Deisseroth's laboratory have developed an optical imaging and optogenetics two photon laser system that uses a single beam to illuminate many sites in three-dimensions.
Mice hemizygous for the MRP8-Cre-ires/GFP transgene are viable and fertile, with the human S100 calcium binding protein A8 (calgranulin A) (MRP8 or S100A8) promoter directing bicistronic Cre and EGFP protein expression to granulocytes and granulocyte/macrophage progenitors (GM
Researchers in Prof. Monte Winslow's laboratory have developed two viable, fertile transgenic mouse strains that enable rapid, simple generation of loss-of-function models with CRISPR/Cas9 mediated genome editing in vivo or ex vivo.
Researchers at Stanford have developed a mouse model of psoriasis that closely mimics human psoriasis. Psoriasis is a chronic inflammatory disorder characterized by itchy, disfiguring skin lesions.
Researchers in Prof. Gerald Crabtree's laboratory have produced a mouse allowing high-throughput screening for activity and inhibition of virtually any chromatin modifier in any murine tissue.
To better understand how the brain processes information and generates behavior, researchers in Dr. Liqun Luo's lab have generated the FosTRAP and ArcTRAP mouse strains.
Dr. Andrea Meredith and Dr. Richard Aldrich have generated a viable mouse knockout KCNMA1, the gene encodes the pore-forming subunit of the BK large conductance calcium-activated potassium channel (also called KCa1.1, SLO1, and MaxiK).
Researchers in Prof. Karl Deisseroth's laboratory have developed specific, inducible animal models for depression that use targeted optogenetic strategies to precisely dissect the neuronal circuits underlying the condition.
Researchers in Dr. Roeland Nusse's laboratory have generated an Axin2CreERT2 knock-in mouse strain that can be used to identify and map stem cells in any tissue. The Wnt/β-catenin signaling pathway is instrumental for stem cell maintenance in multiple tissues.
Hemizygous mice are viable and fertile with no anatomic abnormalities. Transgene expression is observed in aorta, heart, and brain. Transgenicdimethylarginine dimethylaminohydrolase (DDAH) activity is reflected in a reduction of plasma asymmetric dimethylarginine (ADMA).
Researchers in Prof. Liqun Luo's laboratory have developed a mouse model system for in vivo, non-invasive, spatially- and temporally-controlled labeling of individual synapses.
The minicircle is a non-viral DNA vector for non-insertional transgene expression. A typical minicircle contains a transgene expression cassette, and is free of all other plasmid DNA elements, including an antibiotic resistance gene and a plasmid DNA replication origin.
Stanford researchers have developed a highly specific, tunable system to improve the safety, efficacy and deliverability of gene therapy vectors and other biological therapies.