Dr. Mark Kay and colleagues have created antibiotic-selectable, non-silencing plasmid vectors that can be prepared by conventional methods and provide persistent high levels of transgene expression.
Stanford researchers have developed a PCR-based method that detects disease-relevant, isotype-specific antibodies and can be used to diagnose allergy. Allergy is a prevalent immune hypersensitivity disease that affects more than 20% of the US population.
Stanford researchers have patented protein stability regulation methods using destabilizing domains (DDs) optimized for use in humans. The ability to control specific protein abundance in cells is a powerful tool for gene therapy and investigating biological behavior.
Researchers in Dr. Hanlee Ji's lab have developed a targeted sequencing method known as short tandem repeat (STR) sequencing (STR-Seq) which improves target selection specificity to generate only the STR spanning reads.
Researchers in Prof. James Swartz' laboratory have developed a rapid bioluminescence method for detecting and enumerating circulating tumor cells (CTCs) and other rare cells. This invention utilizes novel nanoparticle reagents which can specifically bind to cells of interest.
Researchers in Dr. Karl Deisseroth's lab have engineered a channelrhodopsin variant that can be stimulated by red light and has fast stimulation frequencies. In neurons, channelrhodopsins are light activated protein channels that induce action potential firing.
Researchers in Dr. Dean Felsher's lab have generated a murine hepatocellular carcinoma (HCC) cell line with controllable MYC expression. HCC is one of the most common and incurable malignancies.
Stanford researchers developed BAP1, a strain of E. coli designed to produce complex natural products (particularly polyketides and non-ribosomal peptides) that might otherwise be inaccessible.
Researchers in Prof. Hanlee Ji's laboratory have developed an automated method to capture and directly sequence target DNA with next-generation sequencing.
Dr. Richard Zare and colleagues have developed an inexpensive, fast and simple method for treating polyethylene terephthalate (PET) blood collection tubes (BCTs) to remove bias and interference in various blood analysis procedures.
Researchers in Dr. Shoshana Levy's lab have created a pro B cell lines that provides the first B cell lineage tumors in a C57BL mouse strain. The cell lines, known as H11 and 2F3, were made by transducing mouse bone marrow with BCR-ABL retrovirus.
This invention provides a stem cell culture medium with small molecule inhibitors that can be used to maintain pluripotency in a laboratory atmospheric environment.
Researchers in Dr. Michael Lin's lab have developed a fluorescent voltage sensor for non-invasive optical monitoring of electrical events in living cells in vitro and in vivo.
Researchers in Dr. Roeland Nusse's lab have developed a mouse monoclonal antibody to ROR2 (Nt 2535-2835). ROR2 is a membrane bound receptor tyrosine kinase that is activated by non-canonical Wnt signaling through its association with Wnt5.