Stanford researchers have developed a new therapeutic approach to protect neurons and promote axon regeneration by restoring mitochondrial transport within axons, a key process disrupted in many neurodegenerative diseases.
High-grade gliomas, such as glioblastoma and diffuse midline glioma, are currently incurable diseases with an urgent need for novel therapeutic approaches.
Stanford scientists have developed Plate-C, a high-throughput screening platform that captures genome-wide 3D chromatin architecture as a comprehensive cellular phenotype.
Stanford scientists have developed a high throughput screening method to identify therapeutics known as translational activators to treat protein synthesis disorders and ribosomopathies.
Spiral ganglion neurons (SGNs) are essential for hearing as they transmit electrical signals from the cochlea to the brain. Loss of SGNs causes permanent hearing loss because SGNs do not spontaneously regenerate in humans.
The blood-brain barrier is a huge challenge when it comes to the delivery of therapeutic proteins to treat genetic diseases, injury, and neurodegenerative diseases.
Researchers at Stanford have found that nascent polypeptide-associated complex (NAC) and the apical domain of CCT1, as well as peptide fragments and fusion proteins containing them, can be used to suppress pathological protein aggregation.