The minicircle is a non-viral DNA vector for non-insertional transgene expression. A typical minicircle contains a transgene expression cassette, and is free of all other plasmid DNA elements, including an antibiotic resistance gene and a plasmid DNA replication origin.
Stanford investigators have found a mechanistic difference between p53's ability to induce responses to acute DNA damage (either apoptosis or cell cycle arrest) versus oncogenic stimuli.
A team of Stanford researchers has developed a novel method for quickly and efficiently generating human induced pluripotent stem cells (hiPSCs) using human adipose stem cells (hASCs) as the starting population.
A team of Stanford engineers have developed a low-cost, solution-processed method to fabricate a flexible nanowire mesh that can be used in transparent electrodes, as a replacement for metal oxides (such as ITO, indium tin oxide).
This technology consists of a collection of 48 ALDH cDNA and genomic clones for various ALDH isozymes from Prof. Daria Mochly-RosenÍs lab. DNA fragments of various ALDH genomic and cDNA isozymes were obtained by either PCR, direct DNA synthesis, restriction enzyme digests.
Stanford researchers have developed a highly specific, tunable system to improve the safety, efficacy and deliverability of gene therapy vectors and other biological therapies.
Stanford scientists in Dr. Liqun Luo's laboratory have developed a patented method for site-directed somatic cell recombination and concurrent labeling of "knock in" cells.
This invention is from the Pritzker Neuropsychiatric Disorders Research Consortium, a collaborative research enterprise comprised of several leading academic institutions and based on a long-term relationship between the Pritzker family and scientists at the various institutio
Researchers in the laboratory of Michael Cleary at Stanford University have developed a mouse that lacks the transcription factor Pbx1. Pbx1 is a proto-oncogene that was originally discovered at the site of chromosomal translocations in pediatric acute leukemia.
A Stanford University student wrote and illustrated a soft cover book to teach young children about how it feels to be excluded and how to change that behavior.
Researchers in Dr. Mark Kay's laboratory at Stanford University have designed a new liver-specific expression cassette for inserting genes into double-stranded AAV (adeno-associated virus) vectors for gene therapy.
EDL (gene nomenclature, LIPG; protein, EL), gene targeted, mouse bred to homozygosity for the purposes of biological studying of EDL and the role it plays in lipoprotein metabolism.